Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus
نویسندگان
چکیده
منابع مشابه
1136 Serum Amyloid P Component Binds Fibronectin
Amyloid P component (AP) 1 is a glycoprotein found in all forms of amyloid deposit regardless of the chemical nature of the fibril protein (1-6). It is indistinguishable from a normal plasma protein, serum amyloid P component (SAP), in terms of antigenicity, molecular weight, polypeptide subunit composition, appearance in the electron microscope, and the partial amino acid sequences available h...
متن کاملItraconazole resistance in Aspergillus fumigatus.
Invasive aspergillosis is an increasingly frequent opportunistic infection in immunocompromised patients. Only two agents, amphotericin B and itraconazole, are licensed for therapy. Itraconazole acts through inhibition of a P-450 enzyme undertaking sterol 14alpha demethylation. In vitro resistance in Aspergillus fumigatus to itraconazole correlated with in vivo outcome has not been previously d...
متن کاملThe Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis.
The function of a number of genes in the gliotoxin biosynthetic cluster (gli) in Aspergillus fumigatus remains unknown. Here, we demonstrate that gliK deletion from two strains of A. fumigatus completely abolished gliotoxin biosynthesis. Furthermore, exogenous H(2)O(2) (1 mM), but not gliotoxin, significantly induced A. fumigatus gliK expression (P = 0.0101). While both mutants exhibited signif...
متن کاملIs azole resistance in Aspergillus fumigatus a problem in Spain?
Aspergillus fumigatus complex comprises A. fumigatus and other morphologically indistinguishable cryptic species. We retrospectively studied 362 A. fumigatus complex isolates (353 samples) from 150 patients with proven or probable invasive aspergillosis or aspergilloma (2, 121, and 6 samples, respectively) admitted to the hospital from 1999 to 2011. Isolates were identified using the β-tubulin ...
متن کاملHuman serum amyloid P component is an invariant constituent of amyloid deposits and has a uniquely homogeneous glycostructure.
Human serum amyloid P component (SAP) is a normal plasma protein and the precursor of amyloid P component (AP), a universal constituent of the abnormal tissue deposits in amyloidosis, including Alzheimer disease. We show here that its single N-linked biantennary oligosaccharide does not display the microheterogeneity usually characteristic of glycoproteins. The protein and the glycan structures...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: 2041-1723
DOI: 10.1038/s41467-021-24021-y